NuBodyRx is an authorized Nu Skin retailer. This article is for educational purposes and does not constitute medical advice. Individual results vary. Consult your physician before starting any new supplement regimen, particularly if you have a history of hormone-sensitive conditions.
What Is Estera? Nu Skin's Three-Phase Women's Hormonal Supplement System Explained
Estera is Nu Skin's three-phase women's hormonal supplement system designed to provide targeted phytoestrogen and hormonal support at each distinct stage of a woman's hormonal life. Unlike generic women's supplements that apply a one-size-fits-all approach, Estera recognizes that the hormonal needs of a 35-year-old woman are fundamentally different from those of a 52-year-old post-menopausal woman — and formulates accordingly.
The Three Phases
Estera Phase I — Women's Balance Formula
Who it's for: Women in their childbearing years (~ages 20–40) experiencing hormonal imbalance symptoms — PMS, irregular cycles, mood fluctuations, or hormonal acne.
Key ingredients: DIM (supports healthy estrogen metabolism), flaxseed lignans (adaptogenic phytoestrogens), chasteberry/Vitex (clinically studied for PMS relief), B vitamins (B6, folate).
Shop Estera Phase I — Women's Balance Formula ($94.00)
Estera Phase II — Women's Transitions Formula
Who it's for: Women in perimenopause (~ages 40–52) experiencing hot flashes, night sweats, sleep disruption, mood changes, and accelerating skin aging.
Key ingredients: Soy isoflavones (genistein, daidzein — most extensively studied phytoestrogens for menopausal symptom relief), red clover isoflavones, black cohosh (clinically studied for hot flash and mood support), DIM, flaxseed lignans.
Shop Estera Phase II — Women's Transitions Formula ($94.00)
Estera Phase III — Women's Maintenance Formula
Who it's for: Post-menopausal women (12+ months after the final menstrual period) supporting long-term bone density, cardiovascular health, cognitive function, and skin health.
Key ingredients: Soy isoflavones (ER-β bone and cardiovascular support), calcium + vitamin D3 + vitamin K2 MK-7 (bone health triad), flaxseed lignans (cardiovascular support), methylfolate (homocysteine metabolism).
Shop Estera Phase III — Women's Maintenance Formula ($94.00)
The Science of Phytoestrogens
Phytoestrogens bind preferentially to ER-β (estrogen receptor beta) over ER-α. This selectivity is clinically significant: phytoestrogens provide the protective ER-β-mediated benefits (bone, cardiovascular, skin collagen) with minimal stimulation of the ER-α-mediated proliferative effects associated with hormone-sensitive conditions. This gives phytoestrogen supplementation a fundamentally different safety profile from conventional hormone replacement therapy.
Estera and Skin Health
Estrogen directly stimulates collagen synthesis, hyaluronic acid production, and skin thickness via estrogen receptors in skin fibroblasts. Women lose up to 30% of skin collagen in the first 5 years after menopause. Phytoestrogen supplementation via ER-β activation provides partial support for collagen synthesis that declines with estrogen deficiency. For maximum skin benefit, Estera Phase II and III pair synergistically with Beauty Focus Collagen+ and the ageLOC LumiSpa iO.
When to Transition Between Phases
- Phase I → Phase II: When perimenopausal symptoms begin — irregular periods, hot flashes, night sweats, or significant sleep disruption
- Phase II → Phase III: After 12 consecutive months without a menstrual period (clinical definition of menopause)
Frequently Asked Questions
What is the difference between Estera Phase I, II, and III?
Phase I (Balance) supports hormonal balance during the reproductive years with DIM, chasteberry, and flaxseed lignans. Phase II (Transitions) supports perimenopausal symptom relief with soy and red clover isoflavones, black cohosh, and DIM. Phase III (Maintenance) supports long-term post-menopausal health — bone density, cardiovascular health, and skin — with soy isoflavones, calcium, vitamin D3, and vitamin K2.
Are phytoestrogens safe for women with a history of breast cancer?
Women with a history of hormone-sensitive cancers should consult their oncologist before taking any phytoestrogen supplement. This article does not constitute medical advice.
How long does Estera take to work?
Most women notice improvements in hot flash frequency and sleep quality within 4–8 weeks of consistent Phase II use. Bone density and cardiovascular benefits from Phase III accumulate over months to years. Skin improvements typically become apparent at 8–12 weeks.
Where can I buy Estera?
NuBodyRx.com is an authorized Pharmanex retailer offering all three Estera phases with guaranteed authenticity, fast US shipping, and no membership required. Learn more about Estera.
Related Reading
- What is Estera? — the complete pillar page with full clinical detail
- The Science of Anti-Aging — how hormonal aging affects skin and what to do about it
- The Complete Guide to Nutritional Supplements
- NuBodyRx Knowledge Base