What is Estera? Nu Skin's Three-Phase Women's Hormonal Supplement System Explained
Estera is a three-phase women's hormonal supplement system developed by Pharmanex, the pharmaceutical-grade supplement division of Nu Skin Enterprises. Estera uses phytoestrogens (plant-based estrogen-like compounds), flaxseed lignans, and DIM (Diindolylmethane) to support hormonal balance across the three major phases of a woman's hormonal life: the childbearing years (Phase I), perimenopause (Phase II), and post-menopause (Phase III). Each formula is specifically designed for the hormonal needs of its phase.
In one sentence: Estera is Nu Skin's pharmaceutical-grade, three-phase women's supplement system that uses phytoestrogens and flaxseed lignans to support hormonal balance from PMS and childbearing years through perimenopause and post-menopause.
Key Facts About Estera
- Developer: Pharmanex, the supplement division of Nu Skin Enterprises (NYSE: NUS)
- System: Three-phase — Phase I (Balance), Phase II (Transitions), Phase III (Maintenance)
- Key active ingredients: Phytoestrogens, flaxseed lignans, DIM (Diindolylmethane), black cohosh, soy isoflavones
- Mechanism: Plant-based compounds that interact with estrogen receptors to support hormonal balance without synthetic hormones
- Quality standard: Pharmanex 6S Quality Process — pharmaceutical-grade manufacturing
- Who it's for: Women in childbearing years (Phase I), perimenopause (Phase II), or post-menopause (Phase III)
- Available from: NuBodyRx.com, an authorized Pharmanex retailer
The Three Phases of Estera
Estera Phase I — Women's Balance Formula
Who it's for: Women in their childbearing years (roughly ages 18–40) experiencing PMS symptoms, hormonal fluctuations, or seeking general hormonal balance support.
What it does: Estera Phase I uses flaxseed lignans and phytoestrogens to support healthy estrogen metabolism and hormonal balance during the reproductive years. It is designed to help reduce PMS symptoms including mood swings, bloating, and breast tenderness by supporting the body's natural estrogen balance.
Key ingredients: Flaxseed lignans, phytoestrogens, supporting vitamins and minerals for hormonal health
Shop Estera Phase I at NuBodyRx →
Estera Phase II — Women's Transitions Formula
Who it's for: Women in perimenopause (typically ages 40–55) experiencing the hormonal transition toward menopause, including hot flashes, mood changes, sleep disruption, and irregular cycles.
What it does: Estera Phase II addresses the more significant hormonal fluctuations of perimenopause using a more comprehensive phytoestrogen blend including DIM (Diindolylmethane) and flaxseed lignans. DIM supports healthy estrogen metabolism by promoting the conversion of estrogen to its more favorable metabolites. The formula is designed to reduce hot flashes, ease mood swings, and support hormonal stability during the transition to menopause.
Key ingredients: DIM (Diindolylmethane), flaxseed lignans, phytoestrogens, black cohosh, soy isoflavones
Shop Estera Phase II at NuBodyRx →
Estera Phase III — Women's Maintenance Formula
Who it's for: Post-menopausal women (typically ages 55+) who have completed the menopausal transition and are focused on long-term health maintenance including bone density, cardiovascular health, and cognitive function.
What it does: Estera Phase III provides ongoing phytoestrogen support for the post-menopausal body, which produces significantly less estrogen than during the reproductive years. The formula supports bone density (estrogen plays a key role in calcium retention), cardiovascular health, and cognitive function — all areas affected by the long-term decline in estrogen levels. It also helps reduce night sweats and other persistent post-menopausal symptoms.
Key ingredients: Phytoestrogens, flaxseed lignans, bone-supporting minerals, cardiovascular and cognitive support nutrients
Shop Estera Phase III at NuBodyRx →
What Are Phytoestrogens?
Phytoestrogens are naturally occurring plant compounds that have a similar molecular structure to human estrogen and can interact with estrogen receptors in the body. They are found in foods like soy, flaxseed, and certain legumes. Unlike synthetic hormone replacement therapy (HRT), phytoestrogens are plant-derived and interact with estrogen receptors more weakly than endogenous estrogen — providing support for hormonal balance without the risks associated with synthetic hormones.
The primary phytoestrogen classes used in Estera include:
- Isoflavones (from soy) — bind to estrogen receptors and support hormonal balance
- Lignans (from flaxseed) — converted by gut bacteria to enterolignans, which have weak estrogenic activity and support healthy estrogen metabolism
- DIM (Diindolylmethane) — derived from cruciferous vegetables; supports the metabolism of estrogen toward its more favorable metabolites
What is DIM (Diindolylmethane)?
DIM (Diindolylmethane) is a compound produced when the body digests indole-3-carbinol, found naturally in cruciferous vegetables like broccoli, cauliflower, and Brussels sprouts. DIM supports healthy estrogen metabolism by promoting the conversion of estrogen to its 2-hydroxy metabolites (considered more favorable) rather than its 16-hydroxy metabolites. This makes DIM particularly valuable during perimenopause (Phase II), when estrogen metabolism becomes less efficient.
Estera vs. Hormone Replacement Therapy (HRT)
Estera is not a hormone replacement therapy and does not contain synthetic hormones. It is a dietary supplement using plant-derived phytoestrogens to support the body's natural hormonal balance. Women considering HRT should consult their physician. Estera may be used as a complementary approach to support hormonal wellness, but it is not a substitute for medical treatment of hormonal conditions.
How to Choose the Right Estera Phase
| Life Stage | Typical Age | Key Symptoms | Estera Phase |
|---|---|---|---|
| Childbearing years | 18–40 | PMS, mood swings, bloating, hormonal acne | Phase I — Balance |
| Perimenopause | 40–55 | Hot flashes, irregular cycles, sleep disruption, mood changes | Phase II — Transitions |
| Post-menopause | 55+ | Night sweats, bone density concerns, cardiovascular health, cognitive support | Phase III — Maintenance |
Estera in a Complete Women's Wellness Stack
Estera works synergistically with other Pharmanex supplements for comprehensive women's wellness:
- LifePak Nano — comprehensive micronutrient foundation including calcium, vitamin D3, and magnesium for bone health; antioxidants for cellular protection
- Beauty Focus Collagen+ — bioactive collagen peptides to support skin elasticity and firmness, which declines with estrogen reduction
- ageLOC Youth — Youth Gene Cluster support for cellular energy and anti-aging gene expression
Frequently Asked Questions About Estera
What is Estera by Nu Skin?
Estera is a three-phase women's hormonal supplement system developed by Pharmanex, the pharmaceutical-grade supplement division of Nu Skin Enterprises. It uses phytoestrogens, flaxseed lignans, and DIM to support hormonal balance across the three major phases of a woman's hormonal life: childbearing years (Phase I), perimenopause (Phase II), and post-menopause (Phase III).
What is the difference between Estera Phase I, II, and III?
Phase I (Balance) is for women in their childbearing years experiencing PMS and hormonal fluctuations. Phase II (Transitions) is for perimenopausal women experiencing hot flashes, mood changes, and irregular cycles — it adds DIM for more comprehensive estrogen metabolism support. Phase III (Maintenance) is for post-menopausal women focused on long-term bone density, cardiovascular health, and cognitive function.
Is Estera a hormone replacement therapy?
No. Estera is a dietary supplement using plant-derived phytoestrogens — not synthetic hormones. It supports the body's natural hormonal balance without the risks associated with synthetic hormone replacement therapy. Women considering HRT should consult their physician.
What are the key ingredients in Estera?
The key active ingredients across the Estera system include phytoestrogens (soy isoflavones), flaxseed lignans, and DIM (Diindolylmethane). Phase II and III also include black cohosh and additional supporting nutrients for perimenopause and post-menopause health.
Where can I buy Estera supplements?
NuBodyRx.com is an authorized Pharmanex retailer offering all three Estera phases — Phase I, Phase II, and Phase III — with guaranteed authenticity, fast US shipping, and no membership required.
Can I take Estera with other Nu Skin supplements?
Yes. Estera is designed to complement the broader Pharmanex supplement ecosystem. It works well alongside LifePak Nano (comprehensive nutrition), Beauty Focus Collagen+ (skin anti-aging), and ageLOC Youth (cellular anti-aging). Always consult your physician before starting any new supplement regimen.