ageLOC® R2 Night + Day

ageLOC® R2 Night + Day is Pharmanex's complete 24-hour anti-aging supplement system — a scientifically designed duo that works in synchrony with the body's natural circadian rhythms to support cellular energy during the day and cellular renewal and detoxification at night.

The ageLOC R2 system is built on a fundamental insight: the body's cellular processes are not uniform around the clock. Daytime metabolism is dominated by energy production and utilization; nighttime metabolism shifts to cellular repair, autophagy, and detoxification. A single supplement taken once daily cannot address both phases optimally. ageLOC R2's two-formula approach delivers the right compounds at the right time — aligned with the body's own biological clock.

NuBodyRx is an authorized Nu Skin and Pharmanex retailer. Every ageLOC R2 Night + Day purchased from NuBodyRx.com is 100% authentic, ships fast within the US, and requires no Nu Skin membership or distributor account.

Who This Is For

ageLOC R2 Night + Day is the right choice if you:

• Are 40+ and experiencing declining energy, slower recovery, or reduced mental clarity
• Want a supplement that works with your body's circadian biology rather than against it
• Are already taking ageLOC Youth or LifePak Nano and want to add targeted cellular energy + renewal support
• Are interested in mitochondrial health, NAD+ pathways, and autophagy — the most researched longevity mechanisms
• Want a Pharmanex-grade supplement backed by clinical gene-expression research

It is not a standalone multivitamin — pair with LifePak Nano for complete nutritional coverage.

How It Compares

Compared to popular longevity supplements like Tru Niagen (NR) or Elysium Basis that focus narrowly on NAD+ precursors, ageLOC R2 takes a broader circadian-aligned approach — addressing both the daytime energy production phase and the nighttime autophagy/renewal phase in a single coordinated system, rather than targeting one pathway in isolation.

The Two-Phase System

ageLOC R2 Day — Cellular Energy Support

• Support for mitochondrial function and ATP synthesis
• Support for NAD+ pathway activity — the coenzyme central to cellular energy metabolism that declines with age
• Antioxidant support to protect mitochondria from oxidative stress
• Support for daytime vitality, mental clarity, and physical energy

ageLOC R2 Night — Cellular Renewal and Purification

• Support for autophagy — the cellular self-cleaning process that peaks during sleep
• Support for cellular detoxification pathways
• Support for cellular renewal and regeneration during the overnight repair cycle

Key Benefits

• 24-hour anti-aging coverage — Day and Night formulas address different phases of the cellular aging cycle*
• Supports cellular energy production and mitochondrial function*
• Supports autophagy and cellular detoxification during sleep*
• Targets ageLOC Youth Gene Cluster expression related to cellular energy and renewal*
• Manufactured to Pharmanex's 6S Quality Process

Recommended Protocol

• Day formula: Take in the morning with breakfast
• Night formula: Take in the evening before bed
• Stack: Pairs with ageLOC Youth and LifePak Nano for the complete Pharmanex anti-aging protocol

Frequently Asked Questions

Is ageLOC R2 worth it for cellular energy anti-aging?

For those serious about longevity science, yes. ageLOC R2 is one of the few supplements that addresses both the daytime (energy/NAD+) and nighttime (autophagy/renewal) phases of cellular aging in a single coordinated system — a more complete approach than single-pathway NAD+ supplements.

What is ageLOC R2 and how does it work?

ageLOC R2 is Pharmanex's 24-hour anti-aging supplement system. The Day formula supports cellular energy production and mitochondrial function. The Night formula supports autophagy, cellular detoxification, and renewal during sleep. Together they address the two distinct phases of cellular aging that a single daily supplement cannot target simultaneously.

How is ageLOC R2 different from ageLOC Youth?

ageLOC R2 targets gene expression patterns governing cellular energy (Day) and cellular purification/renewal (Night). ageLOC Youth targets a broader set of YGC patterns associated with overall vitality and longevity. Many users take both as part of a comprehensive anti-aging protocol.

What is autophagy and why does it matter for anti-aging?

Autophagy is the cellular self-cleaning process that identifies and breaks down damaged proteins and dysfunctional organelles. Declining autophagy is a hallmark of cellular aging. It peaks during sleep — the ageLOC R2 Night formula is designed to support this process during its natural peak window.

Can I take ageLOC R2 with ageLOC Youth and LifePak Nano?

Yes — ageLOC R2, ageLOC Youth, and LifePak Nano are designed to work together as the core Pharmanex anti-aging protocol. R2 addresses cellular energy and renewal, Youth addresses YGC gene expression, and LifePak Nano provides the nutritional foundation.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.