What is ageLOC R2?
ageLOC R2 is a two-part daily supplement system from Nu Skin. The two halves do different jobs, and it is worth getting them the right way round: Night is the purification formula, Day is the energy formula.
The complete system is ageLOC R2 Night + Day at $189. The halves are also sold separately: R2 Vitality (Day) at $96 and R2 Night at $105. Bought together as the system you save $12 — modest, but there is no reason to buy them separately unless you genuinely only want one half.
What Nu Skin actually says
We quote the claims rather than dressing them up, because the dressing is where most supplement writing goes wrong.
ageLOC R2 Night: "ageLOC R2 Night optimizes each cell's natural purification process, helping you start each day feeling refreshed and renewed."
ageLOC R2 Vitality (Day): "Start your morning with ageLOC R² Vitality (Day) to help optimize energy production within your cells, so you can recharge, feel revitalized, and take control of a brand-new day."
ageLOC R2 Vitality (Day) — $96
Nu Skin's printed benefit bullets, word for word:
- "Targets the sources of aging."
- "Promotes youthful gene expression"
- "Helps you feel renewed and recharged."
- "Promotes three dimensions of vitality"
- "Raises and sustains baseline energy levels."
- "Helps protect and fortify cells against damage"
- "Helps restore normal cellular function."
ageLOC R2 Night — $105
Nu Skin publishes a single sentence for the Night formula and no benefit bullets: it "optimizes each cell's natural purification process, helping you start each day feeling refreshed and renewed." If you find a longer list attached to R2 Night elsewhere, somebody wrote it themselves.
Who should take it
Adults 35 and over who already have a nutritional foundation in place and want to add something more specific. It pairs with ageLOC Youth and a daily multivitamin.
If you are choosing between them, start with the multivitamin. R2 and ageLOC Youth are additions to a foundation, not a foundation themselves. Which LifePak is right for me? →
If you take prescription medication, are pregnant or nursing, speak to your doctor before starting any supplement.
Day, Night, or both?
The question we get most often, and the answer depends on what you actually want:
- Energy is the complaint — Day formula. It is the only one of the two Nu Skin attaches an energy claim to.
- Sleep quality and waking up flat — Night formula, which is the one about purification and starting the day refreshed.
- Both, and you will remember both — buy the system and save the $12.
- Both, and you know you will forget the evening one — buy the Day formula only. A bottle you do not finish is worse value than the one you do.
How long before you notice anything
Nu Skin publishes no timeline for ageLOC R2 — no weeks, no months — so we are not going to print one either. Any figure you have seen attached to this product, including on this page before September 2026, was somebody's estimate rather than Nu Skin's claim.
What we would suggest instead: write down where you are starting from — energy through the afternoon, how you feel on waking — before the first capsule, and compare against that rather than against how you remember feeling. Supplements are judged over months, and memory is a poor baseline.
The 90 days below is deliberately longer than that judgement takes.
Where to buy
NuBodyRx.com sells the ageLOC R2 Night + Day system, sealed stock shipped direct from Nu Skin. No membership, no account of your own, no monthly order — we are an Independent Nu Skin Brand Affiliate and hold the account so you do not need one. See how that works.
Shop ageLOC R2 Night + Day — $189 →
Frequently asked questions
Where can I buy ageLOC R2 without a Nu Skin membership?
NuBodyRx.com sells ageLOC R2 at retail with no membership, no sign-up and no recurring order. Every product ships sealed from Nu Skin and is backed by NuBodyRx's own 90-day money-back guarantee — three times the 30 days Nu Skin's published US refund policy allows, used or not.
Can I buy the Day or Night formula separately?
Yes. R2 Vitality (Day) is $96 and R2 Night is $105. The combined system at $189 is slightly cheaper than buying both, and the two are designed to work together.
Which one is the purification formula — Day or Night?
Night. It is the formula Nu Skin describes as optimising "each cell's natural purification process". The Day formula is the energy one. A surprising number of write-ups have this backwards.
Should I take ageLOC R2 or ageLOC Youth?
They make different claims. R2 splits into purification and energy; ageLOC Youth is described by Nu Skin as "a revolutionary supplement built on over a decade of research, formulated to help revitalize your body's natural aging defense mechanisms and promote your youth span." Many people take both on top of a daily multivitamin — but if you are starting from nothing, the multivitamin comes first.
What if it doesn't suit me?
Return it within 90 days for a full refund, opened and part-used included. You pay the return postage. Read the policy →
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.